The first step in getting rid of house mice is to stop feeding them. Mice are in your home because they enjoy the shelter and food it has to offer. So, in order to eliminate the food source, you will have to keep food in sealed containers and clean up your house. Get out the vacuum and suck up all the crumbs on the floor, in the couch, under the furniture, and anywhere else food may have been left. Pet food is another major source of mouse food. Try only feeding the pets what they will eat in a sitting.